PAR released an update the other day on their canine trial showing significant clinical, radiological and biomarker improvements. Full PLOS ONE publication here

This was a small trial of only 20 dogs which was randomised and placebo controlled. It was not blinded. There were statistically significant improvements in clinical outcomes. You could easily argue it wasn’t powered enough to read anything into the results

Difficult to react too much into it given those limitations but all broadly supportive of Pentosan being effective in this population.

If you want to get excited, the same biomarker reductions have been noted in a human trial last month.

While nice to have a bit more of a suggestion that the phase 3 human trial is likely to successful, it doesn’t really move the needle

I don’t hold but it would be great for so many people if this turns out to be an effective treatment for Osteoarthritis. Including those brave shareholders.