Forum Topics NUZ NUZ Odds of success

Pinned straw:

Last edited a month ago

AI June 2026 updated to 30-45% odds range. Success is defined by the Healey coordinator as a 30% reduction in the rate of decline of patients by a key measure. The trial is 80% powered.

I'm pretty sure it's just telling me what I want to hear, but there are some keen beans on HC that have dug into the science and think we're closer to 90%. March estimate was a 15-20% chance of a positive readout at the start of the current Healey phase 2/3 trial. Healey is the acid test.

The overall ALS field success rate is 1% but that includes everything ever tried. The analysis then improved for Neurizon based on the safety and current level of evidence.

lastever
Added 2 months ago

I prompted my AI to review today's announcement and it decided that the odds of success should be lifted from 15-20% to 20-25%, based on the fact that the institution and clinicians around the country appear enthusiastic about the trial. The improved data output also modestly increases the appeal to the FDA, if it does achieve a positive trend.

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