Pinned straw:
@thunderhead AD-109 is definitely a factor, but not I think, the dominant one.
Recent broker price-target downgrades for ResMed have generally reflected a de-rating of longer-term growth, with analysts increasingly factoring in emerging competitive and structural risks including GLP-1 therapies such as Zepbound for OSA, the prospective re-entry of Philips into the US sleep-device market, moderating post-recall market-share gains, and slower outer-year growth assumptions. Some brokers have also cited the potential future impact of Apnimed’s AD109 oral OSA therapy as an additional sentiment overhang, particularly for CPAP-intolerant patients, even though its commercial profile and real-world adoption remain uncertain. (The clinical data indeed points to the possibility that over time it may have a wider appeal!)
However, the data presented at the recent ATS Conference of the pooled analysis of two Phase 3 studies indicates efficacy similar to that already released, and AD-109 is widely considered on track for an FDA PDUFA decision in Q1 2027. So that hasn’t changed anything.
My sense is that what we are seeing is that market sentiment is now buying into the thesis that the combination of competitive factors will constrain RMD’s long term growth, even though at this stage, the evidence to support this in terms of new device sales, revenues, and pricing does not yet exist.
Of course, the “short term performance evidence” argument is logically not a robust rebuttal of the bear thesis. You have to also believe that the strong operational performance of the recent quarters will be sustained long into the future. In short, you have to believe that the size on the untreated market, the growing awareness of the importance of sleep health, and the knowledge of availability of drugs to drive new patients into the doctors surgery and increase scripts for CPAP in combination will offset the competitive decline. You have to believe that CPAP will remain the standard of care, as a minimum in combination with other treatments AND that $RMD will remain the dominant market leader.
I remain of that view, for now, although I admit that the market has for the moment moved strongly against that view.
Disc: Held