-Talent: company has noted it is having difficulties finding qualified and experienced talent to run the API facility (in regional Norway)
-Opiate crisis globally as people are increasingly becoming addicted to medication could cause regulatory bodies to regulate against opiate production
-Agricultural difficulties producing poppys (e.g weather) would significantly hinder supply of materials for NRM production, currently a shoratge of poppy seeds globally, indicating limited poppy supply
-Development of non opiate based pain relief (a real threat to TPI given the increasing interest in solving issues with addication)