Forum Topics AVH AVH Real World RECELL Findings

Pinned straw:

Last edited 3 months ago

Nice Release confirming RECELL results in 36% shorter hospital stays vs traditional skin grafting.

Won’t move the dial on the share price as the market is clearly in show-me-the-revenue mode, but this is pleasing as it makes the real-world evidence-based case to use RECELL that much more compelling for Burns hospitals, trauma centres and surgeons. 

The objective would surely be to get to the point where the AVH bods can say to the hospitals “Why on earth are you NOT yet using RECELL”?

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  • A greater proportion of RECELL-treated patients were discharged directly home, indicating improved recovery trajectories
  • Analysis had:
  • 741 adults from the Burn Care Quality platform registry
  • 247 patients treated with RECELL experienced an average 5.6 day reduction in hospital LOS
  • 36% decrease compared to those treated with split thickness skin graft, 494 patients
  • Economically impactful:
  • Based on an average daily inpatient bed cost of $7,554, use of RECELL is associated with potential per patient cost savings of $42,000, exclusive of procedure and rehabilitation costs
  • Reduction in LOS may enable hospitals to treat 13 more patients per bed annually compared to treatment with STSG alone
  • In 2023 alone, US burn cases consumed more than 110,000 ICU days, costing in excess of US$676m


Chart Review

The AVH price has drifted downwards as expected and seems to be forming a reasonable base around $1.32 to $1.33, a tad higher than my expected low of ~$1.28, which goes back to the last June 2022 low. Daily volume has stayed flattish, so its all been pretty orderly thus far.

I topped up last week at $1.355, probably a wee bit impatient, but I have one more top up ready to deploy if it gets below $1.30. 

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Director Top Up

Sorry, forgot to add this.

The top up of 10k shares on market was 15% of his prior holdings of 63,291 ... not much, but this was in isolation, and with his own US$45k coin ... can't be bad!

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Discl: Held IRL and in SM

mikebrisy
Added 3 months ago

@jcmleng I wondered why this was NOT marked price sensitive, but then I realised that it is the same data from the British Burns Association Conference that they rolled out at the last investor presentation (2Q).

There are a couple of points to make about it's significance.

First, this plays into the same US Healthcare issue with RFK going after the price of dermal substitutes (The event that led to $PNV to make their "non-announcement" which was market price sensitive, and their unbelievable trading halt. WTF!!) Data like this is exactly what is used to justify pricing decisions. (Spend $10,000 on a treatment to save $40,000 in fewer days in hospital etc. etc.)

Second, $AVH are "rolling the pitch" in the EU, ahead of the expected granting of the International CE Mark for Recell and Recell Go in Q4. This data could not come at a better time for $AVH to negotiate pricing and reimbursement for when they launch in EU/Australia.

(I much prefer Jim Corbett's low key approach of keeping the market informed, than the constant dramas about nothing from DW.)

My almost 3% RL position initiated in May has now fallen 30% to a smidge over 20%. I thought we'd seen the bottom in May, but that was before the CMS coding debacle. My gut is telling me that I should be taking a bigger position here, but I have been resisting. I mean, EV/Revenue is a crazy at <1>

Maybe this is where I should be directling the rest of my $4DX windfall? Talk about short term multi-bagger potential. .... but oh, what a serial disappointer ... until it doesn't!

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jcmleng
Added 3 months ago

@mikebrisy, I did wonder about the source of the data, but why it got my attention is that it is data US National Burn Registry data, with a much smaller pupulation size of 741.

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The BBA data was a much bigger dataset of 6,300 patients.

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I didn't think much of it not being marked price sensitive as the 36% LOS reduction is the exact same finding as the BBA study, so in that sense, nothing "new" from an outcome perspective. But that a totally different dataset is comfirming 36% is great news!

It would seem I now need to dig into RFK's rubbish - I was trying to ignore the noise, but that sounds unwise!

I think this reporting season, I have decided to pay more attention to the robustness of the "underlying product" in my look back. I am still liking what I am seeing with AVH as nothing has really changed other than more evidence that RECELL works and works well ...

Discl: Held IRL and in SM

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mikebrisy
Added 3 months ago

Well spotted, sir @jcmleng! (I've been too focused on another part of the anatomy this week!). Good to have fellow StrawPeople to keep us on the straight and narrow!

I think what is going on is that multiple studies are being published on US National Burns Data Registry content, using the same underlying 6,300 patient dataset. So, I've dug a bit deeper.

The first publication announcing the availability of the un-analysed dataset and characterising it was "Skin Is In: A National Analysis of Skin Cell Suspension Autograft in Burn Centers Hoppe, Athena ; Carter, Jeffrey ; Phillips, Bart ; Phelan, Herbert ; Schoen, Jonathan ; Ivanko, Anastasiya ; Miles, Victoria. Journal of burn care & research, 2025-04, Vol.46 (Supplement_1), p.S322-S322

Note: Carter and Miles, because I am coming back to them.

This was then analysed by J. Carter and B. Phillips in "The Clinical Impact of Skin Cell Suspension Autograft from a National Registry Perspective," British Burn Association Annual Meeting, 2025. This was the research presented at the 2Q Results call. And I think this was a pre-peer reviewed preliminary release of the research findings.

The one announced today is a reference to a presentation at the 2025 European Burn Association Congress in Berlin, Germany by Victoria Miles.

Because the earlier BBA research hasn't been published in a journal, and either I can't access the UK Conference Proceeedings, or they haven't come out yet, it is hard to do a detailed comparison of the two research outcome.

However, both the BBA Conference Presentation and today's reports from the European Burns Congress reference the following key result: "a matched analysis of 741 adults from the Burn Care Quality Platform registry, patients treated with RECELL (n=247) experienced an average 5.6-day reduction in hospital LOS, a 36% decrease compared to those treated with STSG (n=494; p < 0>

Basically, to me it just looks like the same major body of research is being presented to different audiences.

The Northern Hemishpere summer is a peak time for research conferences. (I remember the halcyon days of my PhD research and travelling to Turin in August 1992 to present my PhD work in progress at a 3-day conference, only then to bolt on 3 days in Florence and 3 in Rome with my fiance ... ahh, the for the academic life. That conference presentation from me was a repackaging of the same work I had presented a few months earlier (May) at an IChemE conference in my university town in the UK. All academics do this, to drive their research stats.)

JE Carter is a common thread here ... he's a key ReCell KOL! Here's what my BA dug up on him.

Who is Dr. Jeffrey E. Carter?

  • Position and Affiliations:
  • Dr. Carter serves as Medical Director of the Burn Center at University Medical Center in New Orleans and is an Associate Professor of Surgery at LSU Health Sciences Center (New Orleans School of Medicine) learn.traumacenters.orgLSU.
  • Prior to his current role, he was Associate Director of the Wake Forest Baptist Health Burn Center and played leadership roles in surgical education, including founding a Center for Experiential and Applied Learning learn.traumacenters.org.
  • Research Focus and Contributions:
  • He has been a leader in developing spray-on skin (ReCell ®) technology for burn treatment, enabling accelerated healing with reduced donor skin use—up to an 80:1 expansion ratio LSU+1LSU Health New Orleans Med School.
  • In a 2020 study, Dr. Carter co-authored work showing that Autologous Skin Cell Suspension (ASCS) significantly reduced hospital length of stay per percentage of total body surface area burned compared to traditional split-thickness skin grafts Oxford Academic.
  • He also contributed to research demonstrating the safety and effectiveness of combining ASCS with meshed skin grafts, significantly reducing the donor area needed for acute burns Oxford Academic.
  • Achievements and Recognition:
  • During his fellowship in burn surgery, he received the Moyer Award from the American Burn Association—the top in-training honor in burn care learn.traumacenters.org.
  • Under his leadership, the burn-related mortality rate in New Orleans parishes dropped from nearly 8% to about 3.6%, outperforming the national average LSU Health New Orleans Med SchoolLSU.


The presenter at this latest 2025 European Burn Association Congress in Berlin, Germany is Victoria Miles. She is Assistant Professor of Clinical Surgery (Burn Surgery) at LSU Health New Orleans; practices at University Medical Center New Orleans (UMCNO) Burn Center. So she is a colleague/collaborator with JE Carter. He is the senior (Associate Professor) and so I guess she is on his research group (Assistant Professor).

So this now all makes sense. It is all the same research.

A common practice in research groups is that ahead of the summer conference season, they divvy up the leading conferences between them. So, for example, in my own case in 1992, I presented in the UK and Italy, and my supervisor took the same work elsewhere (can't remember the specifics, it was so long ago). The papers aren't identical. For example, earlier one might be a preliminary analysis or just focus on a key results, whereas later papers might go into more complete analysis, and later still the work will be submitted and be published in a peer-reviewed journal. But it is all the same underlying body of work.

So, how is this journey of nostalgia at all relevant to $AVH as an investment?

All the regulators and pricing reimbursement decision-makers (and RFK) need to be aware of this work. And members of the regulatory bodies also attend these conferences. Presenting research at conferences in medtech is a key marketing activity!


After mulling this over during lunch, I added another 1% of my RL portfolio to $AVH at $1.35. (And I have also placed a trade on SM.)

This one is a slow burn, but I think it is going to come good over the next 2-3 years, so I am going to keep averaging in on continued weakness.

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