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Pinned straw:

Last edited a month ago

Just wondering if anyone (@mikebrisy @Nnyck777 @BendigoInvesto) had any comment on their latest update?

Thanks

C

Record DAYBUE™ net sales of US$101.1 million in Q3 2025, up 11%

from Q3 2024

Q3 Highlights:

from Q2 2025

• Q3 2025 DAYBUE™ (trofinetide) net sales of US$101.1 million, up 11% from Q3 2024 and up 5%

• For the first time more than 1,000 patients received shipments

• Largest quarter-over-quarter increase in referrals since launch driven by expanded team

• 74% of prescriptions to new patients were written by physicians in the community setting outside

centers of excellence

• Named patient supply programs active across multiple regions outside North America

• Neuren earned Q3 2025 royalty income of A$16.4 million, up 24% from Q3 2024 and up 12% from

Q2 2025

• Acadia narrowed full year 2025 DAYBUE US net sales guidance to US$385 – 400 million (previously

US$380 - 405 million), implying full year 2025 US royalty income for Neuren of A$63 – 66 million

(previously A$62 - 67 million)

mikebrisy
Added a month ago

@Chagsy yes, I will write my notes in the coming days. (I’ve been busy organising wife’s 60th birthday and hosting overseas guest, so have been neglecting timely SM posts.)

TLDR: sold $NEU in RL and SM today

  • $NEU still below my valuation but ….
  • DAYBUE sales below my low case
  • August Canada “do not reimburse” decision not covered by anyone except in $ACAD analyst Q&A
  • above point bodes poorly for EU/UK reimbursement/price
  • unclear how much of latest Q result is due to “early access-non-USA” scripts
  • 12-m persistency c. 50% but c. 18-m is “45%”
  • NNZ2591 catalysts … a long way away(??) given challenges of rare disease enrolment.


Basically, I’m concerned we could see successive quarters of underwhelming DAYBUE news flow before we get positive NNZ2591 catalysts.

I have therefore decided to pocket reasonable $NEU profits and continue to monitor. If I’m right, DAYBUE underperformance could erode SP over next 12m before NNZ2591 catalysts kick in.

Disc. no longer held

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BendigoInvesto
Added a month ago

@Chagsy @mikebrisy I have also sold out today, the upside seems to be reduced and I see better returns elsewhere.

I will be continuing to monitor Neuren, love the company, just seems a bit asymmetrical in the wrong direction right now.

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SudMav
Added a month ago

Looking forward to hearing what @mikebrisy has to say when he gets time, as I couldnt make the call

Thank you however for the gentle nudge to do some more maintenance due diligence on Neuren. My quick analysis isn't too far from what has been mentioned above:

  • The do not reimburse decision in Canada really hurts the dial, and it means that the likelihood of exceeding $500m USD in a calendar year will be touch and go next year depending on growth in North America.
  • EU in Q1 next year is critical now without the USD milestone, as my forward estimates account for them meeting this target by start Q3 next year. Meeting this target will likely double NPAT for next year once you factor in the expenditure for the NNZ-2591 trials.
  • Next 12 months will be a waiting game for any material announcements.
  • I did some scenario testing in my calculations to play around with royalty payments and timeframe for the $50m payment for exceeding $500m revenue is received. Two years in a row sub $100m NPAT will pose some definite headwinds for the current price and multiple, even though the future could be very bright.


Like others here, I have trimmed my RL position and will likely look to sell the remaining portion in a week or so when i pass 12 month ownership. Have a sell on my SM position as well.


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Nnyck777
Added 4 weeks ago

Hi Chagsy,

I appreciate everyone’s insight here. I agree there could be a period of lull over the next 12 months if the market continues to only perceive value from Daybue and continues to ignore NNZ-2591.

The share price still lags the $25-$31 price tag in analyst reports. So on Daybue alone there is still room to lift. Numbers were largely in line with my expectations and Jon has been clear that Q4 was when the traction (or lack there of) of Acadias bolstered sales force is likely to be felt. I think that Q4 may surprise to the upside.

Further to this I anticipate that Neu may receive break through designation for HIE which will be pretty significant. It could also be a catalyst for partnering or further boost takeover talks.

I unlike others here continue to accumulate in the dips. I want to be fully invested and have my 12 months CG discount if a take over offer comes before the completion of Phase 3 which is still a possibility.

I haven’t found a compelling alternative and I have been very happy with Neuren and its management.

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