Forum Topics CGS CGS Aduhelm Controversy
Nnyck777
Added 3 years ago

@Bjbart. An excellent straw. I agree with a multitude of your points….a great person to follow. I also enjoy your insights into other companies we have in common. There are more and more Alzheimer’s drugs coming to market so a well placed product for increasing trials. Eagerly watching the Japanese app media.

@Nerdag please keep doing what you are doing. You are offering a great bear case. This helps everyone to stay on their toes and reassess their bullcase.

Thanks for both of your work.

Cheers

Nnyck777

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nerdag
Added 3 years ago

@bjbart well done on making 120% so far.

I bring my knowledge of neuroscience to the table. That knowledge isn't the same knowledge base as needed in investing, and you know what, there is every possibility that I might be wrong.

Without going into a long-winded rant about health funding and politics, the TLDR version is that neuroscience and psychopharmacology have been the next big growth areas in medicine for the last 25 years. I am sceptical that we will see it achieve parity in funding with other areas in my lifetime. This has implications for a company that sits squarely in the neuroscience field.

My purpose in bringing up the bear case is to keep highlighting that one needs to keep in focus what the company does (cognitive testing in clinical trials) and what it might do (end user screening), and whether the latter is meaningful.

A lot of the commentary here and elsewhere seems to be that because we are all getting old and dementing, Cogstate is a sure bet. I'm not convinced as most here seem to be. That's ok, because disagreement makes a market.

I've previously compared Cogstate to a mining services company, and you know what, mining services tend to do better than the miners over time. Cogstate may well be the same. Or it may not.

If I'm wrong, I've missed out on an opportunity. I'm ok with that. I don't consider the time I've put into arguing my perspective to be inordinate.

I do think there is something that might be observed in the often emotive language being used to argue the bull case every time I post a contribution about this company.

Let's keep playing the ball, shall we?

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AlphaAngle
Added 3 years ago

@bjbart 

My opinion but any drug that the entire expert panel refuses to endorse and then members actually resign because of how much they disagree is concerning. Can you find another example of this happening? because it's really that unusual. Then there is the length of time its approved for 9 years which is more than twice as long as its phase 3 trial took. Also a brick wall when you have a drug that doesn't work with a significant side effect profile is unfortunate but to me reeks of sunk cost bias and false hope. Anyway I'm sure its clear I think this was a stupid decision and it lacks transparency. 

I just wanted to highlight the existential risk I think it creates where your downside could be sudden and significant even if you view that as unlikely. If this never comes to pass I actually think CGS has a bright future as each study further entrenches it as the standard to which other studies will want to replicate to ensure comparability. 

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bjbart
Added 3 years ago

I generally don't  follow FDA approvals close enough to know, but I agree it does sound dodgey and there's no question that the way this happened increases risk compared to if it was all smooth sailing. I'm sure those closer to the industry have ideas of what went on.  Whether it impacts future research only time will tell. 

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AlphaAngle
Added 3 years ago

Upon reflection perhaps my straw should have been tagged #risks rather than #bearcase.

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bjbart
Added 3 years ago

Looks like the FDA has also given Donanemab breakthrough therapy approval too, so the ball is rolling 

 

https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-receives-us-fdas-breakthrough-therapy

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reddogaustin
Added 3 years ago

Here is an article on Livewiremarkets from Michael Frazis.

His fund specialises in biotech and monstor growth stocks. He wasn't a fan of the approval. But it is outside my circle of competence to know either way.

https://www.livewiremarkets.com/wires/a-disastrous-drug-approval

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