PAR released an update the other day on their canine trial showing significant clinical, radiological and biomarker improvements. Full PLOS ONE publication here

This was a small trial of only 20 dogs which was randomised and placebo controlled. It was not blinded. There were statistically significant improvements in clinical outcomes. You could easily argue it wasn’t powered enough to read anything into the results

Difficult to react too much into it given those limitations but all broadly supportive of Pentosan being effective in this population.

If you want to get excited, the same biomarker reductions have been noted in a human trial last month.

While nice to have a bit more of a suggestion that the phase 3 human trial is likely to successful, it doesn’t really move the needle

I don’t hold but it would be great for so many people if this turns out to be an effective treatment for Osteoarthritis. Including those brave shareholders.

Thanks for bringing this to my attention. I had a patient who was a racehorse owner with terrible arthritis.

He had noticed the amazing effect it had on his animals and had somehow managed to convince the vet that looked after his racehorses to let him have " a couple of extra vials" in case they lost some. 
He swore he was a new man since injecting himself with Cartrofen and was convinced there was some big pharma conspiracy as to why it wasn't available to humans!

id completely forgotten about it til now!

EDIT: This is in no way an endorsement of this drug, and absolutely not a suggestion to start injecting yourself with equine products. Furthermore anecdotes are in no way proof.  This was just a funny story I thought I'd share!