Hi @edgescape it is interesting to review how far Trof has come. The turn around time for Nnz2591 should be significantly faster than 3 years. Jon has often made this point. There was quite a delay in preparation between phase 2 and 3 Trof as this was a new area for the company in drug development. Jon has stated there were many lessons learnt and that phase 3 prep is already well and truly advanced for Nnz2591. If you trust Jon and his team which in my opinion I have never seen any reason to doubt him the turn around time should be significantly quicker than 3 years.